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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 218 - 224 (7page)
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Background/Aims: von Willebrand factor antigen (vWF-Ag) is a noninvasive predictor of portal hypertension that serves as a negative prognostic marker in various malignancies. Increased portal hypertension is associated with higher postoperative morbidity and decreased survival after hepatectomy. The purpose of this study was to determine the correlation between vWF-Ag, postoperative morbidity and oncological outcome. Methods: This analysis includes 55 patients who underwent liver resection for hepatocellular carcinoma (HCC) between 2008 and 2015 with available preoperative vWF-Ag levels. The primary endpoints were postoperative complications and long-term outcome, including overall and disease-free survival. Results: The median plasma level of vWF-Ag was 191% (range, 162.5% to 277%). There was a significant correlation between vWF-Ag levels and tumor size in the resected specimens (p=0.010, r=0.350). Patients who developed any grade of postoperative complication had significantly higher preoperative vWF-Ag levels (216% [range, 178% to 283.25%] vs 176% [range, 148% to 246%], p=0.041). Median overall survival was 39.8 months in patients with high vWF-Ag levels (≥191%) compared with 73.4 months in patients with low levels (<191%, p=0.007). Of note, there was a remarkable disparity in the number of patients who died of HCC with low versus high vWF-Ag levels (14.8% vs 28.6%, p=0.011). Conclusions: vWF-Ag may serve as a prognostic marker for the outcome of patients undergoing liver resection for HCC that is closely connected to tumor size, postoperative complication rate and long-term outcome.
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참고문헌 (37)
참고문헌 신청
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008 : GLOBOCAN 2008 / Int J Cancer 127:2893~2917
Forner A / 2012 / Hepatocellular carcinoma / Lancet 379:1245~1255
Altekruse SF / 2009 / Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 / J ClinOncol 27:1485~1491
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
European Association for the Study of the Liver / 2012 / EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
Forner A / 2012 / Hepatocellular carcinoma / Lancet 379:1245~1255
Altekruse SF / 2009 / Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 / J ClinOncol 27:1485~1491
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
European Association for the Study of the Liver / 2012 / EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
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