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논문 기본 정보

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학술저널
저자정보
Yoon, In Cheol (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Cho, Jeong Hyeon (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Choi, Heejin (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Choi, Young Hoon (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Lim, kyu Min (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Choi, Sung Hwa (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Han, Jae Ho (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Jeong, Hyeon Ju (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine) Lee, Hong Sub (Department of Internal Medicine, Myongji Hospital, Seonam University College of Medicine)
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영남대학교 의과대학 영남의대학술지 영남의대학술지 제33권 제1호
발행연도
2016.1
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13 - 20 (8page)

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Background: Prevalence of adenoma in males aged 40-49 years in Korea was higher than expected. The aim of this study was to investigate the prevalence and risk factors of colorectal adenoma in males aged 40-49 years. Methods: Total 1,902 asymptomatic subjects with a mean age of $47.9{\pm}6.7years$, who underwent a screening colonoscopy in a health promotion center of Myongji Hospital from 2010 to 2013 were enrolled in this study. We conducted a case-control study to determine the risk factors for adenoma. The subjects were classified into two groups (adenoma vs. controls). To validate the diagnostic value of carcinoembryonic antigen (CEA) for adenoma, area under the receiver operating characteristic curve (AUROC) was calculated. Results: At least one colorectal adenoma was identified in 385 subjects (20.2%). Among these 385 subjects, 372 subjects were found to have a non-advanced adenoma, 13 subjects had an invasive adenoma. One subject had cancer. Male sex, age, smoking, metabolic syndrome, and elevated CEA level were significantly associated with a colorectal adenoma in univariate analysis. However, metabolic syndrome was not significant in multivariate analysis. In the male group, the AUROC of CEA for colorectal adenoma was 0.600 (0.543 to 0.656) in non-smokers under 50 years of age, and 0.615 (0.540 to 0.690) in smokers under 50 years of age. Conclusion: Male sex, smoking, and high levels of CEA seem to be associated with colorectal adenoma. High levels of CEA and smoking may be diagnostic markers for any colorectal adenoma in Korean males aged 40-49 years.

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