지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 13 - 20 (8page)
- DOI
- http://dx.doi.org/10.12701/yujm.2016.33.1.13
이용수
초록· 키워드
오류제보하기
Background: Prevalence of adenoma in males aged 40-49 years in Korea was higher than expected. The aim of this study was to investigate the prevalence and risk factors of colorectal adenoma in males aged 40-49 years.
Methods: Total 1,902 asymptomatic subjects with a mean age of 47.9±6.7 years, who underwent a screening colonoscopy in a health promotion center of Myongji Hospital from 2010 to 2013 were enrolled in this study. We conducted a case-control study to determine the risk factors for adenoma. The subjects were classified into two groups (adenoma vs. controls). To validate the diagnostic value of carcinoembryonic antigen (CEA) for adenoma, area under the receiver operating characteristic curve (AUROC) was calculated.
Results: At least one colorectal adenoma was identified in 385 subjects (20.2%). Among these 385 subjects, 372 subjects were found to have a non-advanced adenoma, 13 subjects had an invasive adenoma. One subject had cancer. Male sex, age, smoking, metabolic syndrome, and elevated CEA level were significantly associated with a colorectal adenoma in univariate analysis. However, metabolic syndrome was not significant in multivariate analysis. In the male group, the AUROC of CEA for colorectal adenoma was 0.600 (0.543 to 0.656) in non-smokers under 50 years of age, and 0.615 (0.540 to 0.690) in smokers under 50 years of age.
Conclusion: Male sex, smoking, and high levels of CEA seem to be associated with colorectal adenoma.
High levels of CEA and smoking may be diagnostic markers for any colorectal adenoma in Korean males aged 40-49 years.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / Int J Cancer 127:2893~2917
정규원 / 2014 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011 / Cancer Research and Treatment 46(2):109~123
Rex DK / 2009 / American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected] / Am J Gastroenterol 104:739~750
Sung JJ / 2015 / An updated Asia Pacific Consensus Recommendations on colorectal cancer screening / Gut 64:121~132
이보인 / 2012 / Korean Guidelines for Colorectal Cancer Screening and Polyp Detection / Clinical Endoscopy 45(1):25~43
정규원 / 2014 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011 / Cancer Research and Treatment 46(2):109~123
Rex DK / 2009 / American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected] / Am J Gastroenterol 104:739~750
Sung JJ / 2015 / An updated Asia Pacific Consensus Recommendations on colorectal cancer screening / Gut 64:121~132
이보인 / 2012 / Korean Guidelines for Colorectal Cancer Screening and Polyp Detection / Clinical Endoscopy 45(1):25~43
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