지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.2
- 발행연도
- 2021.6
- 수록면
- 121 - 131 (11page)
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초록· 키워드
오류제보하기
Dysbiosis is a microbial imbalance, which often causes diseases and can be triggered by diet. Here, we determined the effect of a nutritionally balanced diet rich in vegetables and whole grains alone and/or in combination with probiotics on the gut microbiota of healthy adults. We conducted a parallel-group randomized trial enrolling 63 healthy participants who were administered either a balanced diet (B-diet group), a probiotic capsule containing Lactobacillus plantarum PMO 08 (probiotics group), or a balanced diet plus probiotic capsule (synbiotics group) once daily for 2 weeks. The gut microbiota of each participant was analyzed via 16S ribosomal RNA MiSeq-based sequencing. Gastrointestinal symptoms and defecation habits were evaluated using questionnaires. The B-diet group showed significantly reduced Firmicutes-to-Bacteroidetes ratio (P<0.05) and abundances of the genera Blautia (P<0.01), Dorea (P<0.05), and Lachnoclostridium (P<0.05). Furthermore, the abundance of Bacteroides increased (P<0.05) compared to baseline levels. In the synbiotics group, Lactobacillus abundance increased significantly (P<0.05) and defecation difficulty decreased (P<0.05), confirming a synergistic effect of combined intake. All groups showed a significant reduction in the abundance of Clostridiaceae (P<0.001) and alleviation of bloating symptoms (P<0.05). Moreover, the relative abundance of Faecalibacterium significantly increased in the probiotics group (P<0.05). Therefore, the individual or combined intake of a nutritionally balanced diet and L. plantarum PMO 08 beneficially modifies the gut microbiota with the potential to alleviate gastrointestinal symptoms and improve defecation habits.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (50)
참고문헌 신청
Arumugam M / 2011 / Enterotypes of the human gut microbiome / Nature 473:174~180
Barrett HL / 2018 / A vegetarian diet is a major determinant of gut microbiota composition in early pregnancy / Nutrients 10:890
Cândido FG / 2018 / Impact of dietary fat on gut microbiota and low-grade systemic inflammation : mechanisms and clinical implications on obesity / Int J Food Sci Nutr 69:125~143
Chae L / 2016 / The effects of Korean-DASH diet on metabolic syndrome, insulin resistance and gut microbiota
Chang CJ / 2019 / Next generation probiotics in disease amelioration / J Food Drug Anal 27:615~622
Barrett HL / 2018 / A vegetarian diet is a major determinant of gut microbiota composition in early pregnancy / Nutrients 10:890
Cândido FG / 2018 / Impact of dietary fat on gut microbiota and low-grade systemic inflammation : mechanisms and clinical implications on obesity / Int J Food Sci Nutr 69:125~143
Chae L / 2016 / The effects of Korean-DASH diet on metabolic syndrome, insulin resistance and gut microbiota
Chang CJ / 2019 / Next generation probiotics in disease amelioration / J Food Drug Anal 27:615~622
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UCI(KEPA) : I410-ECN-0101-2021-594-001866205