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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.101 No.5
- 발행연도
- 2021.11
- 수록면
- 257 - 265 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Little is known about liver resection (LR) in hepatocellular carcinoma (HCC) patients older than 75 years of age. This study aimed to compare the postoperative and long-term outcomes of hepatectomy in this patient population according to operation period.
Methods: This study included 130 elderly patients who underwent LR for solitary treatment-naïve HCC between November 1998 and March 2020. Group 1 included patients who underwent LR before 2016 (n = 68) and group 2 included those who underwent LR during or after 2016 (n = 62).
Results: The proportion of major LR, anatomical LR, and laparoscopic LR (LLR) in group 1 was significantly lower than those in group 2. Also, the median operation time, amount of blood loss, hospitalization length, rates of intraoperative blood transfusion, and complications in group 2 were less than those in group 1. In the subgroup analysis of group 1, high proteins induced by vitamin K absence or antagonist-II, long hospitalization, and LLR were closely associated with mortality. In the subgroup analysis of group 2, however, none of the factors increased mortality. Nevertheless, the presence of tumor grade 3 or 4 and the incidence of microvascular invasion were higher in group 1 than in group 2, and the disease-free survival and overall survival were better in group 2 than in group 1 because of minimized blood loss and quicker recovery period by increased surgical techniques and anatomical approach, and LLR.
Conclusion: LR in elderly HCC patients has been frequently performed recently, and the outcomes have improved significantly compared to the past.
Methods: This study included 130 elderly patients who underwent LR for solitary treatment-naïve HCC between November 1998 and March 2020. Group 1 included patients who underwent LR before 2016 (n = 68) and group 2 included those who underwent LR during or after 2016 (n = 62).
Results: The proportion of major LR, anatomical LR, and laparoscopic LR (LLR) in group 1 was significantly lower than those in group 2. Also, the median operation time, amount of blood loss, hospitalization length, rates of intraoperative blood transfusion, and complications in group 2 were less than those in group 1. In the subgroup analysis of group 1, high proteins induced by vitamin K absence or antagonist-II, long hospitalization, and LLR were closely associated with mortality. In the subgroup analysis of group 2, however, none of the factors increased mortality. Nevertheless, the presence of tumor grade 3 or 4 and the incidence of microvascular invasion were higher in group 1 than in group 2, and the disease-free survival and overall survival were better in group 2 than in group 1 because of minimized blood loss and quicker recovery period by increased surgical techniques and anatomical approach, and LLR.
Conclusion: LR in elderly HCC patients has been frequently performed recently, and the outcomes have improved significantly compared to the past.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (37)
참고문헌 신청
Korc-Grodzicki B / 2014 / Surgical considerations in older adults with cancer / J Clin Oncol 32:2647~2653
Yeun-Yoon Kim / 2019 / Gadoxetic acid-enhanced magnetic resonance imaging: Hepatocellular carcinoma and mimickers / Clinical and Molecular Hepatology 25(3):223~233
Takuji Torimura / 2021 / Optimizing the management of intermediate-stage hepatocellular carcinoma: Current trends and prospects / Clinical and Molecular Hepatology 27(2):236~245
In Sik Shin / 2020 / Hepatocellular carcinoma in old age: are there any benefits of liver resection in old age? / Annals of Surgical Treatment and Research 99(2):65~71
Young Eun Chon / 2021 / Hepatocellular carcinoma statistics in South Korea / Clinical and Molecular Hepatology 27(3):512~514
Yeun-Yoon Kim / 2019 / Gadoxetic acid-enhanced magnetic resonance imaging: Hepatocellular carcinoma and mimickers / Clinical and Molecular Hepatology 25(3):223~233
Takuji Torimura / 2021 / Optimizing the management of intermediate-stage hepatocellular carcinoma: Current trends and prospects / Clinical and Molecular Hepatology 27(2):236~245
In Sik Shin / 2020 / Hepatocellular carcinoma in old age: are there any benefits of liver resection in old age? / Annals of Surgical Treatment and Research 99(2):65~71
Young Eun Chon / 2021 / Hepatocellular carcinoma statistics in South Korea / Clinical and Molecular Hepatology 27(3):512~514
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