Luteolin inhibits H2O2-induced cellular senescence  via modulation of SIRT1 and p53

Ri Zhe Zhu; Bing Si Li; Shang Shang Gao; Jae Ho Seo; Byung-Min Choi

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자료유형: 학술저널

저자정보: Ri Zhe Zhu (Department of Biochemistry Wonkwang University School of Medicine Iksan 54538 Korea) Bing Si Li (Department of Biochemistry Wonkwang University School of Medicine Iksan 54538 Korea) Shang Shang Gao (Department of Biochemistry Wonkwang University School of Medicine Iksan 54538 Korea) Jae Ho Seo (Department of Biochemistry Wonkwang University School of Medicine Iksan 54538 Korea) Byung-Min Choi (Department of Biochemistry Wonkwang University School of Medicine Iksan 54538 Korea)

저널정보: 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제4호

발행연도: 2021.1

수록면: 297 - 305 (9page)

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Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative stress-induced cellular senescence and its molecular mechanism using hydrogen peroxide (H2O2)-induced cellular senescence model in House Ear Institute-Organ of Corti 1 cells (HEI-OC1). Our results showed that luteolin attenuated senescent phenotypes including alterations of morphology, cell proliferation, senescence-associated ? -galactosidase expression, DNA damage, as well as related molecules expression such as p53 and p21 in the oxidant challenged model. Interestingly, we found that luteolin induces expression of sirtuin 1 in dose- and time-dependent manners and it has protective role against H2O2-induced cellular senescence by upregulation of sirtuin 1 (SIRT1). In contrast, the inhibitory effect of luteolin on cellular senescence under oxidative stress was abolished by silencing of SIRT1. This study indicates that luteolin effectively protects against oxidative stress-induced cellular senescence through p53 and SIRT1. These results suggest that luteolin possesses therapeutic potentials against age-related hearing loss that are induced by oxidative stress.

#Cellular senescence #Hydrogen peroxide #Luteolin #Sirtuin 1 #Tumor suppressor protein p53

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