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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 253 - 261 (9page)
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Background/Aims: This study aimed to characterize the changes in the gut microbiota of irritable bowel syndrome (IBS) patients and to investigate the consequent alterations in bacterial functions. Methods: We performed 16S rRNA metagenomic sequencing and a phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analyses using fecal samples from control (n=12) and diarrhea-dominant IBS patients (n=7). Results: The samples were clustered by the principal coordinates analysis depending on the presence of IBS (p=0.003). In the IBS patients, the abundances of Acidaminococcaceae, Sutterellaceae, and Desulfovibrionaceae were significantly increased, while those of Enterococcaceae, Leuconostocaceae, Clostridiaceae, Peptostreptococcaceae, and Lachnospiraceae were significantly decreased. The PICRUSt results indicated that two orthologues involved in secondary bile acid biosynthesis were significantly decreased in IBS patients. Modules involved in multidrug resistance, lipopolysaccharide biosynthesis, the reductive citrate cycle, and the citrate cycle were significantly increased in the IBS patients. In contrast, modules involved in cationic antimicrobial peptide resistance, and some transport systems were more abundant in controls than in IBS patients. Conclusions: Changes in the gut microbiota composition in IBS patients lead to alterations in bacterial functions, such as bile acid transformation and the induction of inflammation, which is a known pathophysiological mechanism of IBS.
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참고문헌 (40)
참고문헌 신청
Mearin F / 2016 / Bowel disorders / Gastroenterology 150:1393~1407
Camilleri M / 2017 / Irritable bowel syndrome : pathophysiology and current therapeutic approaches / Handb Exp Pharmacol 239:75~113
Bhattarai Y / 2017 / Irritable bowel syndrome: a gut microbiota-related disorder? / Am J Physiol Gastrointest Liver Physiol 312:G52
Saulnier DM / 2011 / Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome / Gastroenterology 141:1782~1791
Jeffery IB / 2012 / An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota / Gut 61:997~1006
Camilleri M / 2017 / Irritable bowel syndrome : pathophysiology and current therapeutic approaches / Handb Exp Pharmacol 239:75~113
Bhattarai Y / 2017 / Irritable bowel syndrome: a gut microbiota-related disorder? / Am J Physiol Gastrointest Liver Physiol 312:G52
Saulnier DM / 2011 / Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome / Gastroenterology 141:1782~1791
Jeffery IB / 2012 / An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota / Gut 61:997~1006
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