지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 546 - 553 (8page)
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초록· 키워드
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Background/Aims: Fecal calprotectin (FC) is a marker of intraluminal intestinal inflammation. Intestinal inflammation may contribute to the pathophysiology of irritable bowel syndrome (IBS). This study evaluated FC levels in children with IBS and differences in FC levels in children stratified by IBS subtype and healthy controls (HCs). Methods: A total of 157 children with IBS and 56 HCs aged 4–16 years (119 boys, 94 girls, mean age of 9.48 years) were included in this prospective study. Children with IBS were diagnosed using the Rome III criteria and classified into 4 subtypes: IBS with constipation (IBS-C, n=37), IBS with diarrhea (IBS-D, n=54), IBS with alternating constipation and diarrhea (IBS-M, n=49), and IBS unsubtyped (IBS-U, n=17); postinfectious IBS (PI-IBS) was also considered. The FC concentration in stool samples was analyzed using an enzyme-linked immunosorbent assay. All participants answered a questionnaire regarding several demographic and clinical characteristics. Results: Children with IBS had significantly higher levels of FC than the HCs (88.71 µg/g vs. 17.77 µg/g). Among the 4 IBS subtypes, the FC concentration was highest in children with IBS-D, followed by those with IBS-M, IBS-C, and IBS-U (169.94 µg/g vs. 45.04, 31.22, and 33.52 µg/g, respectively), and these differences were statistically significant. For PI-IBS, 90% of cases were in the IBS-D group. Conclusions: The FC level was significantly higher in children with IBS than in HCs and differed depending on the IBS subtype, supporting the notion that IBS is a type of low-grade bowel inflammation.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Devanarayana NM / 2015 / Epidemiology of irritable bowel syndrome in children and adolescents in Asia / J Pediatr Gastroenterol Nutr 60:792~798
Longstreth GF / 2006 / Functional bowel disorders / Gastroenterology 130:1480~1491
Rafiz Abdul Rani / 2016 / Irritable bowel syndrome and inflammatory bowel disease overlap syndrome: pieces of the puzzle are falling into place / Intestinal research 14(4):297~304
von Arnim U / 2016 / Fecal calprotectin : a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome / Clin Exp Gastroenterol 9:97~103
Gecse K / 2008 / Increased faecal serine protease activity in diarrhoeic IBS patients : a colonic lumenal factor impairing colonic permeability and sensitivity / Gut 57:591~599
Longstreth GF / 2006 / Functional bowel disorders / Gastroenterology 130:1480~1491
Rafiz Abdul Rani / 2016 / Irritable bowel syndrome and inflammatory bowel disease overlap syndrome: pieces of the puzzle are falling into place / Intestinal research 14(4):297~304
von Arnim U / 2016 / Fecal calprotectin : a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome / Clin Exp Gastroenterol 9:97~103
Gecse K / 2008 / Increased faecal serine protease activity in diarrhoeic IBS patients : a colonic lumenal factor impairing colonic permeability and sensitivity / Gut 57:591~599
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