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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 14 (14page)
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Background: Monitoring the full spectrum of causes of death among human immunodeficiency virus (HIV) patients has become increasingly important as survival improves because of highly active antiretroviral therapy. However, there are no recently published data regarding the changes in the causes of death among HIV patients based on year of HIV diagnosis, and the impact of low CD4 count at the time of HIV diagnosis on the clinical outcome is still unclear in Korea. Methods: A retrospective cohort study was conducted with 801 patients with HIV infection who were followed up at a tertiary university hospital and diagnosed with HIV between July 1984 and October 2019. The causes of death were analyzed by descriptive analysis based on CD4 count and the year of HIV diagnosis. Kaplan–Meier and log rank tests were performed t compare the prognosis between the CD4 < 200 cells/mm3 and CD4 ≥ 200 cells/mm3 groups. Results: Among 801 patients, 67 patients were eligible for the death cause analysis. Infection-related death accounted for 44 patients (65.7%) and non-infection related death accounted for 23 patients (32.4%). Pneumocystis pneumonia (29.9%) was the single most common cause of death in both past and present cases, and tuberculosis (19.4%) was the second leading cause of death from infections, but the frequency has declined in recent year Causes of infection-related death have decreased, whereas non-infection related causes of death have increased remarkably. Malignancy-related death was the most common cause of non-infection related death. Acquired immunodeficiency syndrome (AIDS) non-related malignancy accounted for 11.9%, whereas AIDS-related malignancy accounted for 6.0% of the total death among HIV patients. No significant statistical differences were found in mortality rate (P = 0.228), causes of death (P = 0.771), or survival analysis (P = 0.089) betwee the CD4 < 200 cells/mm3 and CD4 ≥ 200 cells/mm3 groups. Conclusion: Being diagnosed with CD4 < 200 cells/mm3 at the time of HIV diagnosis was not an indicator of greater risk of death compared with the CD4 ≥ 200 cells/mm3 group. Malignant tumors have become an important cause of death in recent years, and an increasing tendency of AIDS-non-related malignancy causes has been observed.
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참고문헌 (29)
참고문헌 신청
Mocroft A / 2003 / Decline in the AIDS and death rates in the EuroSIDA study : an observational study / Lancet 362(9377):22~29
Palella FJ Jr / 1998 / Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators / N Engl J Med 338(13):853~860
Samji H / 2013 / Closing the gap : increases in life expectancy among treated HIV-positive individuals in the United States and Canada / PLoS One 8(12):e81355
Mills EJ / 2011 / Life expectancy of persons receiving combination antiretroviral therapy in low-income countries : a cohort analysis from Uganda / Ann Intern Med 155(4):209~216
Kee MK / 2009 / Improvement in survival among HIV-infected individuals in the Republic of Korea : need for an early HIV diagnosis / BMC Infect Dis 9(1):128
Palella FJ Jr / 1998 / Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators / N Engl J Med 338(13):853~860
Samji H / 2013 / Closing the gap : increases in life expectancy among treated HIV-positive individuals in the United States and Canada / PLoS One 8(12):e81355
Mills EJ / 2011 / Life expectancy of persons receiving combination antiretroviral therapy in low-income countries : a cohort analysis from Uganda / Ann Intern Med 155(4):209~216
Kee MK / 2009 / Improvement in survival among HIV-infected individuals in the Republic of Korea : need for an early HIV diagnosis / BMC Infect Dis 9(1):128
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