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자료유형
학술저널
저자정보
Yang Jung-Ho (Department of Preventive Medicine Chonnam National University Medical School Hwasun Korea.) Kweon Sun-Seog (Department of Preventive Medicine Chonnam National University Medical School Hwasun Korea.) Lee Young-Hoon (Department of Preventive Medicine) Choi Seong-Woo (Department of Preventive Medicine Chosun University Medical School Gwangju Korea.) Ryu So-Yeon (Department of Preventive Medicine Chosun University Medical School Gwangju Korea.) Nam Hae-Sung (Department of Preventive Medicine Chungnam National University Medical School Daejeon Korea.) Park Kyeong-Soo (Cardiocerebrovascular Center Mokpo Jung-Ang Hospital Mokpo Korea.) Kim Hye-Yeon (Gwangju-Jeonnam Regional Cardiocerebrovascular Center Chonnam National University Hospital Gwangju) Shin Min-Ho (Department of Preventive Medicine Chonnam National University Medical School Hwasun Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.30
발행연도
2021.1
수록면
1 - 9 (9page)

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Background: Several studies have reported conflicting results regarding the relationship between alcohol consumption and cortisol levels. However, the causality between alcohol consumption and cortisol levels has not been evaluated. Methods: This study examined 8,922 participants from the Dong-gu Study. The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was used as an instrumental variable for alcohol consumption. The association between the genetically predicted alcohol consumption and cortisol level was evaluated with Mendelian randomization (MR) using two-stage least squares regression. Results: Alcohol consumption was positively associated with the serum cortisol level in both sexes in the observational analysis. In the MR analysis, the genetically predicted alcohol consumption was positively related to the cortisol level in men, with cortisol levels increasing by 0.18 µg/dL per drink per day. However, there was no relationship in women in the MR analysis. Conclusion: The predicted alcohol consumption according to the ALDH2 rs671 polymorphism was positively related to the cortisol levels, suggesting a causal relationship between alcohol consumption and cortisol levels.

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