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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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In terminally ill patients, organ transplantation could be recommended as the treatment of choice. In Korea, living donor liver or kidney transplantation is much more frequent than deceased donor transplantation due to organ shortages from deceased donors. ABO or HLA incompatibility in transplantation can be a major barrier in living donor transplantation. Currently, the rate of ABO incompatible organ transplantation accompanied by desensitization is 20∼25% of living donor transplantation, and the blood bank laboratory plays an active role by plasmapheresis. The desensitization of HLA incompatible transplantation in highly sensitized patients is more difficult than that of ABO incompatible transplantation. The HLA antibody is not easy to remove and it is difficult to prevent sensitization. In addition, setting the target treatment goals and predicting the treatment outcomes based on the HLA antibody results are problematic. Therefore, a range of desensitization protocols have been attempted and various therapeutic goals have been introduced. This article reviews the various desensitization methods for antibody removal focusing on HLA incompatible kidney transplantation, and discusses the prognosis of desensitization methods for antibody removal based on the literature.
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등록된 정보가 없습니다.
참고문헌 (73)
참고문헌 신청
Opelz G / 1997 / Impact of HLA compatibility on survival of kidney transplants from unrelated live donors / Transplantation 64:1473~1475
Kim YN / 2014 / Current issues in ABO-incompatible kidney transplantation / J Korean Transplant Soc 28:5~12
이승훈 / 2018 / ABO Incompatible Living Donor Liver Transplantation: A Single Center Experience / Korean Journal of Transplantation 32(4):84~91
Kwon KH / 2002 / The results of renal transplantation after lymphocyte cross - match negative conversion by combination therapy with plasmapheresis, intravenous gamma globulin and potent immunosuppresants in patients with positive LCM / J Korean Transplant Soc 16:172~177
Roy R / 1990 / The importance of serum dithiothreitol treatment in crossmatching selection of presensitized kidney transplant recipients / Transplantation 50:532~534
Kim YN / 2014 / Current issues in ABO-incompatible kidney transplantation / J Korean Transplant Soc 28:5~12
이승훈 / 2018 / ABO Incompatible Living Donor Liver Transplantation: A Single Center Experience / Korean Journal of Transplantation 32(4):84~91
Kwon KH / 2002 / The results of renal transplantation after lymphocyte cross - match negative conversion by combination therapy with plasmapheresis, intravenous gamma globulin and potent immunosuppresants in patients with positive LCM / J Korean Transplant Soc 16:172~177
Roy R / 1990 / The importance of serum dithiothreitol treatment in crossmatching selection of presensitized kidney transplant recipients / Transplantation 50:532~534
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