지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia. The Dementia with Lewy Bodies Consortium has revised DLB consensus diagnostic criteria. We reviewed recent (fourth) clinical diagnosis criteria and treatment options. The revised DLB clinical criteria included clinical features and updated diagnostic biomarkers. Compared with third criteria, they removed suggestive features and reassigned rapid eye movement sleep behavior disorder (RBD) in core clinical features with fluctuating cognition, recurrent visual hallucination, and parkinsonism. They classified biomarkers into two groups, indicative and supportive biomarkers, according to diagnostic specificity and evidence quality. Indicative biomarkers included reduced dopamine transporter uptake in basal ganglia demonstrated by single-photon emission CT or positron emission tomography, low uptake 123Iodine- metaiodobenzylguanidine myocardial scintigraphy, and RBD in polysomnography. In treatment of DLB, cholinesterase inhibitor can improve cognitive function and activities of daily living. Neuroleptics should use with caution due to sensitivity in DLB.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Burton EJ / 2009 / Medial temporal lobe atrophy on MRI differentiates Alzheimer’s disease from dementia with Lewy bodies and vascular cognitive impairment : a prospective study with pathological verification of diagnosis / Brain 132:195~203
O’Brien JT / 2014 / 18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias / J Nucl Med 55:1959~1965
Lim SM / 2009 / The 18F-FDG PET cingulate island sign and comparison to 123Ibeta-CIT SPECT for diagnosis of dementia with Lewy bodies / J Nucl Med 50:1638~1645
Graff-Radford J / 2014 / Dementia with Lewy bodies : basis of cingulate island sign / Neurology 83:801~809
Bonanni L / 2008 / EEG comparisons in early Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease with dementia patients with a 2-year follow-up / Brain 131:690~705
O’Brien JT / 2014 / 18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias / J Nucl Med 55:1959~1965
Lim SM / 2009 / The 18F-FDG PET cingulate island sign and comparison to 123Ibeta-CIT SPECT for diagnosis of dementia with Lewy bodies / J Nucl Med 50:1638~1645
Graff-Radford J / 2014 / Dementia with Lewy bodies : basis of cingulate island sign / Neurology 83:801~809
Bonanni L / 2008 / EEG comparisons in early Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease with dementia patients with a 2-year follow-up / Brain 131:690~705
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