지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.26 No.4
- 발행연도
- 2020.1
- 수록면
- 486 - 495 (10page)
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초록· 키워드
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Background/AimsPsychobiotics are probiotics or prebiotics that, upon ingestion in adequate amounts, yield positive influence on mental health via microbiota-gut-brain axis regulation to modulate the circulating cytokines, chemokines, neurotransmitters, or neurotrophins levels. We have recently shown that a psychobiotic combination (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175; CEREBIOME) significantly improved depression symptoms in patients with depression. Recent animal data suggest the influence of the gut microbiota on brain-derived neurotrophic factor (BDNF), which was shown to correlate with antidepressant response in depressive patients. Therefore, we conducted this exploratory post hoc analysis of BDNF levels to clarify the mechanism of action of this psychobiotic in our cohort. MethodsOur study was a double-blind, randomized controlled trial of patients with low-to-moderate depression receiving either a probiotic combination, prebiotic or placebo. From the 110 patients randomized in the trial, 78 were included in this post hoc analysis (probiotic, n = 28; prebiotic and placebo, n = 25). We compared serum BDNF levels from participants at baseline and endpoint, and assessed the Pearson correlation between depression severity and BDNF levels for each intervention. ResultsWe found that post-intervention BDNF levels were significantly different between groups (P < 0.001). Furthermore, BDNF levels increased significantly in the probiotic group compared to both the prebiotic (P < 0.001) and placebo groups (P = 0.021), which inversely correlated with depression severity compared to placebo (ANOVA/ANCOVA, P = 0.012; Pearson, r = ?0.79, P < 0.001). In the prebiotic group, BDNF levels reduced but not significantly compared with placebo group (P > 0.05). ConclusionEight-week supplementation with B. longum and L. helveticus in depressive patients improved depression symptoms, possibly by increasing BDNF levels.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Dinan TG / 2013 / Psychobiotics : a novel class of psychotropic / Biol Psychiatry 74:720~726
Bermúdez-Humarán LG / 2019 / From probiotics to psychobiotics : live beneficial bacteria which act on the brain-gut axis / Nutrients 11:890
Ibáñez CF / 1995 / Neurotrophic factors : from structure-function studies to designing effective therapeutics / Trends Biotechnol 13:217~227
Pérez-Navarro E / 2005 / Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum / J Neurochem 92:678~691
Fossati P / 2004 / Neuroplasticity : from MRI to depressive symptoms / Eur Neuropsychopharmacol 14(suppl 5):S503~S510
Bermúdez-Humarán LG / 2019 / From probiotics to psychobiotics : live beneficial bacteria which act on the brain-gut axis / Nutrients 11:890
Ibáñez CF / 1995 / Neurotrophic factors : from structure-function studies to designing effective therapeutics / Trends Biotechnol 13:217~227
Pérez-Navarro E / 2005 / Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum / J Neurochem 92:678~691
Fossati P / 2004 / Neuroplasticity : from MRI to depressive symptoms / Eur Neuropsychopharmacol 14(suppl 5):S503~S510
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