지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 394 - 401 (8page)
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Purpose: In the present study, we aimed to evaluate the initial tumor location as a prognostic factor in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Methods: Between March 2002 and January 2007, a total of 179 patients with stage II/III breast cancer underwent NAC followed by breast surgery. Using physical and radiologic findings, patients were grouped by their initial tumor location into inner/both quadrant (upper/lower inner quadrant involvement +/– multicentric tumor involving outer quadrant; n=97) and outer quadrant (n=82) tumor groups. All patients received neoadjuvant docetaxel/doxorubicin chemotherapy. One hundred two patients underwent modified radical mastectomy and 77 patients underwent breastconserving surgery. Adjuvant radiotherapy (RT) and hormonal therapy were administered after surgery when indicated. While 156 patients underwent postoperative RT, 23 did not. The median follow-up duration was 61.1 (12–106) months. Results: The 5-year disease-free survival (DFS) and overall survival rates of all patients were 74.8% and 89.9%, respectively. Patients with inner/ both quadrant tumors had lower 5-year DFS than those with outer quadrant tumors (67.7% vs. 83.4%, respectively; hazard ratio [HR]=1.941, p=0.034). A nodal ratio >25% was also an independent adverse prognostic factor for DFS (HR=3.276; p<0.001). There was no significant difference in DFS (p=0.592) after RT on the internal mammary node (IMN). Treatment failed in 44 out of 179 patients (24.6%), of which 27 patients had inner/ both quadrant tumors. Twenty-one out of 27 patients had distant failures. Conclusion: Among breast cancer patients treated with NAC, those with inner/both quadrant tumors had lower DFS than those with outer quadrant tumors. More aggressive neoadjuvant and/or adjuvant chemotherapy with IMN RT is required for improved disease control and long-term survival.
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참고문헌 (24)
참고문헌 신청
Gralow JR / 2008 / Preoperative therapy in invasive breast cancer:pathologic assessment and systemic therapy issues in operable disease / J Clin Oncol 26:814~819
Mauri D / 2005 / Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis / J Natl Cancer Inst 97:188~194
Chia S / 2008 / Locally advanced and inflammatory breast cancer / J Clin Oncol 26:786~790
Buchholz TA / 2008 / Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: a National Cancer Institute conference / J Clin Oncol 26:791~797
Gaffney DK / 2003 / Diminished survival in patients with inner versus outer quadrant breast cancers / J Clin Oncol 21:467~472
Mauri D / 2005 / Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis / J Natl Cancer Inst 97:188~194
Chia S / 2008 / Locally advanced and inflammatory breast cancer / J Clin Oncol 26:786~790
Buchholz TA / 2008 / Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: a National Cancer Institute conference / J Clin Oncol 26:791~797
Gaffney DK / 2003 / Diminished survival in patients with inner versus outer quadrant breast cancers / J Clin Oncol 21:467~472
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