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자료유형
학술저널
저자정보
엄태영 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea) 이유진 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea) 김정빈 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea) 박인석 (인제대학교부속상계백병원) 곽금희 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea) 조현진 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea) 양근호 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea) 김기환 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea) 배병노 (Department of Surgery Inje University Sanggye Paik Hospital Seoul Korea)
저널정보
대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.37 No.4
발행연도
2021.8
수록면
259 - 265 (7page)
DOI
10.3393/ac.2020.00759.0108

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Purpose: It is known that as the T stage of a carcinoma progresses, the prognosis becomes poorer. However, there are few studies about factors that affect the prognosis of T4 advanced colon cancer. This study aimed to identify the prognostic factors associated with disease-free survival (DFS) and overall survival (OS) in T4 colon cancer.Methods: Patients diagnosed with stage T4 on histopathology after undergoing curative surgery for colon cancer between March 2009 and March 2018 were retrospectively analyzed for factors related to postoperative survival. Primary outcomes were DFS and OS.Results: Eighty-two patients were included in the study. DFS and OS of the pathologic (p) T4b group were not inferior to that of the pT4a group. Multivariate analysis showed that differentiation (hazard ratio [HR], 4.994; P = 0.005), and laparoscopic surgery (HR, 0.323; P = 0.008) were significant prognostic factors for DFS, while differentiation (HR, 7.904; P ≤ 0.001) and chemotherapy (HR, 0.344; P = 0.038) were significant prognostic factors for OS.Conclusion: Tumor differentiation, laparoscopic surgery, and adjuvant chemotherapy were found to be significant prognostic factors in patients with T4 colon cancer. Adjuvant chemotherapy and curative resections by laparoscopy might improve the prognosis in these patients.

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