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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,337 - 1,344 (8page)
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초록· 키워드
오류제보하기
Positive fluid balance is a risk factor for mortality in critically ill patients, especially those requiring continuous renal replacement therapy (CRRT). However, the association between daily fluid balance and various organ impairments remains unclear. This study investigated the impacts of daily fluid balance prior to CRRT on organ dysfunction, as well as mortality in critically ill patients. We identified daily fluid balance between intensive care unit (ICU) admission and CRRT initiation. According to daily fluid balance, the time to CRRT initiation and the rate of organ failure based on the sequential organ failure assessment (SOFA) score were assessed. We recruited 100 patients who experienced CRRT for acute kidney injury. CRRT was initiated within 2 [0, 4] days. The time to CRRT initiation was shortened in proportion to daily fluid balance, even after the adjustment for the renal SOFA score at ICU admission (HR 1.14, P = 0.007). Based on the SOFA score, positive daily fluid balance was associated with respiratory, cardiovascular, nervous, and coagulation failure, independent of each initial SOFA score at ICU admission (HR 1.36, 1.26, 1.24, and 2.26, all P < 0.05). Ultimately, we found that positive fluid balance was related with an increase in the rate of 28-day mortality (HR 1.14, P = 0.012). Positive daily fluid balance may accelerate the requirement for CRRT, moreover, it can be associated with an increased risk of multiple organ failure in critically ill patients.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Rivers E / 2001 / Early goal-directed therapy in the treatment of severe sepsis and septic shock / N Engl J Med 345:1368~1377
Prowle JR / 2010 / Fluid balance and acute kidney injury / Nat Rev Nephrol 6:107~115
Bouchard J / 2009 / Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury / Kidney Int 76:422~427
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network / 2006 / Comparison of two fluid-management strategies in acute lung injury / N Engl J Med 354:2564~2575
Upadya A / 2005 / Fluid balance and weaning outcomes / Intensive Care Med 31:1643~1647
Prowle JR / 2010 / Fluid balance and acute kidney injury / Nat Rev Nephrol 6:107~115
Bouchard J / 2009 / Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury / Kidney Int 76:422~427
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network / 2006 / Comparison of two fluid-management strategies in acute lung injury / N Engl J Med 354:2564~2575
Upadya A / 2005 / Fluid balance and weaning outcomes / Intensive Care Med 31:1643~1647
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