지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 77 - 84 (8page)
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초록· 키워드
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Adding either macrolide or fluoroquinolone (FQ) to β-lactam has been recommended for patients with severe community-acquired pneumonia (CAP). However, due to the limited evidence available, there is a question as to the superiority of the two combination therapies. The MEDLINE, EMBASE, Cochrane Central Register, Scopus, and Web of Science databases were searched for systematic review and meta-analysis. A total of eight trials were analyzed. The total number of patients in the β-lactam plus macrolide (BL-M) and β-lactam plus fluoroquinolone (BL-F) groups was 2,273 and 1,600, respectively. Overall mortality of the BL-M group was lower than that of the BL-F group (19.4% vs. 26.8%), which showed statistical significance (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.49 to 0.94; P = 0.02). Length of hospital stay was reduced in the BL-M group compared to the BL-F group (mean difference, −3.05 days; 95% CI, −6.01 to −0.09; P = 0.04). However, there was no significant difference in length of intensive care unit (ICU) stay between the two groups. Among patients with severe CAP, BL-M therapy may better reduce overall mortality and length of hospital stay than BL-F therapy. However, we could not elicit strong conclusions from the available trials due to high risk of bias and methodological limitations.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Angus DC / 2001 / Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care / Crit Care Med 29:1303~1310
Mandell LA / 2007 / Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults / Clin Infect Dis 44(Suppl 2):S27~S72
Rodríguez A / 2007 / Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock / Crit Care Med 35:1493~1498
이진화 / 2007 / Outcomes and Prognostic Factors for Severe Community-Acquired Pneumonia that Requires Mechanical Ventilation / The Korean Journal of Internal Medicine 22(3):157~163
Sligl WI / 2013 / Severe community-acquired pneumonia / Crit Care Clin 29:563~601
Mandell LA / 2007 / Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults / Clin Infect Dis 44(Suppl 2):S27~S72
Rodríguez A / 2007 / Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock / Crit Care Med 35:1493~1498
이진화 / 2007 / Outcomes and Prognostic Factors for Severe Community-Acquired Pneumonia that Requires Mechanical Ventilation / The Korean Journal of Internal Medicine 22(3):157~163
Sligl WI / 2013 / Severe community-acquired pneumonia / Crit Care Clin 29:563~601
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