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논문 기본 정보

자료유형
학술저널
저자정보
Dongke Wang (Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science a) Chaofan Duan (Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science a) Xiaohao Zhang (Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science a) Junying Xu (Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science a) Xiaohua Hou (Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science a) Xuelian Xiang (Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science a)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.28 No.4
발행연도
2022.10
수록면
580 - 588 (9page)
DOI
10.5056/jnm21156

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"Background/Aims Lyon consensus differentiates acid exposure time (AET) as physiological, borderline, and pathological. Mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave index (PSPWi) are believed to increase diagnostic yield of gastroesophageal reflux disease (GERD) and correlate with symptom outcome of proton pump inhibitor (PPI) treatment. We aim to explore the clinical characteristics and the correlation of pH-impedance parameters with PPI response in Chinese patients with different AET levels. Methods We retrospectively investigated 177 patients with typical reflux symptoms who received esophageal function tests. The demographics, GERD questionnaire scores, the proportion of esophagitis and PPI responders, and manometric and pH-impedance parameters were compared among patients with AET < 4%, 4-6%, and > 6%. In patients with AET ≥ 4%, manometric and pH-impedance parameters were compared between PPI responders and non-responders. Results Among 177 patients, 69 (39.0%) had AET 4-6%, and 53 (29.9%) had AET > 6%. The demographics, esophagogastric junction type, and occurrence of ineffective esophageal motility were similar between patients with AET 4-6% and > 6%, but different from AET < 4%. MNBI and PSPWi were different among different AET levels, but similar between PPI responders and non-responders in patients with AET ≥ 4%. Conclusions It is reasonable to set 4% as a threshold to define pathological AET in Chinese patients. MNBI and PSPWi could identify GERD patients, but may not correlate with PPI response of Chinese GERD patients."

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