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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제43권
- 발행연도
- 2021.12
- 수록면
- 1 - 6 (6page)
- DOI
- 10.1186/s40902-021-00326-2
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초록· 키워드
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Background4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.
MethodIn this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1?100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.
ResultsIn the results, SIRT3 (100 μM at 24 h) and SIRT6 (1?100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).
Conclusion4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
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