지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,107 - 1,116 (10page)
- DOI
- 10.3349/ymj.2021.62.12.1107
이용수
초록· 키워드
오류제보하기
Purpose: Indications for local excision in patients with rectal cancer remain controversial. We reviewed factors affecting survival rate and treatment effectiveness in cancer recurrence after local excision among patients with rectal cancer.
Materials and Methods: A total of 831 patients was enrolled. Of these, 391 patients were diagnosed with primary rectal cancer and underwent local excision. A retrospective observational study was performed on patients who underwent full-thickness local excision for rectal cancer.
Results: The median duration of follow-up was 61 months. The overall recurrence rate was 11.5%. The rate of local recurrence was 5.1%. Five-year overall survival rate among recurrent patients was 66.8%; the rate among patients who underwent salvage operation due to recurrence was 84.7%, compared with 44.2% among patients treated with non-operative management (p<0.001). Multivariate analysis of disease-free survival identified distance from the anal verge (p=0.038) and histologic grade (p=0.047) as factors predicting poor prognosis. Multivariate analysis of overall survival showed that age (p<0.001), serum carcinoembryonic antigen (CEA) levels (p=0.001), and histologic grade (p=0.013) also affected poor prognosis. In subgroup analysis of patients with recurrence, 25 patients underwent reoperation, while 20 patients did not. For 5-year overall survival rate, there was a significant difference between 84.7% of the reoperation group and 44.2% of the non-operation group (p<0.001).
Conclusion: The risk factors affecting overall survival rate after local excision were age 65 years or older, preoperative CEA level 5 or higher, and high histologic grade. In cases of recurrence after local excision of rectal cancer, salvage operation might improve overall survival.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Siegel RL / 2020 / Colorectal cancer statistics, 2020 / CA Cancer J Clin 70:145~164
허혁 / 2018 / Characteristics and Survival of Korean Patients With Colorectal Cancer Based on Data From the Korea Central Cancer Registry Data / Annals of Coloproctolgy 34(4):212~221
Damin DC / 2014 / Evolving treatment strategies for colorectal cancer : a critical review of current therapeutic options / World J Gastroenterol 20:877~887
Young DO / 2017 / Local excision of rectal cancer / Surg Clin North Am 97:573~585
Nastro P / 2005 / Local excision of rectal cancer : review of literature / Dig Surg 22:6~15
허혁 / 2018 / Characteristics and Survival of Korean Patients With Colorectal Cancer Based on Data From the Korea Central Cancer Registry Data / Annals of Coloproctolgy 34(4):212~221
Damin DC / 2014 / Evolving treatment strategies for colorectal cancer : a critical review of current therapeutic options / World J Gastroenterol 20:877~887
Young DO / 2017 / Local excision of rectal cancer / Surg Clin North Am 97:573~585
Nastro P / 2005 / Local excision of rectal cancer : review of literature / Dig Surg 22:6~15
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