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논문 기본 정보

자료유형
학술저널
저자정보
Dong Junguo (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National) Huang Junfeng (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National) Liu Jiaxing (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National) Tang Yufang (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National) Sivapalan Dhinesan (International College of Education Guangzhou Medical University Guangzhou Guangdong China.) Lai Kefang (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National) Zhong Nanshan (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National) Luo Wei (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National) Chen Ruchong (Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.5
발행연도
2021.9
수록면
799 - 807 (9page)
DOI
10.4168/aair.2021.13.5.799

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Gastroesophageal reflux disease (GERD) is a common cause of chronic cough (CC). However, the diagnosis of GERD associated with CC based on 24-hour esophageal pH-monitoring or favorable response to empirical anti-reflux trials is invasive and time-consuming. Lipid-laden macrophages (LLMs) are supposed to be a biomarker for micro-aspiration of gastric content in the respiratory tract. This study was conducted to collect LLMs by the sputum induction technique and observe the relationship among the amount of LLMs, cough severity, parameters of 24-hour esophageal pH-monitoring and therapeutic response. The 24-hour esophageal pH-monitoring and sputum induction were performed on 57 patients with suspected GERD associated with CC. Thirty-four patients were followed up after empirical anti-reflux trials of 8 weeks to record the therapeutic response. Lipid-laden macrophage index (LLMI), a semiquantitative counting of LLMs, showed no significant correlation with the values of 24-hour esophageal pH monitoring at the proximal or remote electrode. No difference in LLMI or DeMeester score, as well as cough symptom association probability, were found between the responders and the non-responders. Reflux symptoms were more common in the responders (50%) compared to the non-responders (6%) (P < 0.05). Our study suggests that LLMI shows limited utility in clinically diagnosing GERD associated with CC as an underlying etiology or in predicting response to anti-reflux therapy. Anti-reflux therapy is more effective for CC patients with reflux symptoms than for those without.

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