Incidence of congenital hypothyroidism by gestational age: a retrospective observational study

Ha Young Jo; Eun Hye Yang; Young Mi Kim; Soo-Han Choi; Kyung Hee Park; Hye Won Yoo; Su Jeong Park; Min Jung Kwak

doi:10.12701/jyms.2022.00059

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자료유형: 학술저널

저자정보: Ha Young Jo (Department of Pediatrics Pusan National University Hospital Busan Korea) Eun Hye Yang (Department of Pediatrics Pusan National University Hospital Busan Korea) Young Mi Kim (Department of Pediatrics Pusan National University Hospital Busan Korea) Soo-Han Choi (Department of Pediatrics Pusan National University Hospital Busan Korea) Kyung Hee Park (Department of Pediatrics Pusan National University Hospital Busan Korea) Hye Won Yoo (Department of Pediatrics Pusan National University Hospital Busan Korea) Su Jeong Park (Department of Pediatrics Pusan National University Hospital Busan Korea) Min Jung Kwak (Department of Pediatrics Pusan National University Hospital Busan Korea)

저널정보: 영남대학교 의과대학 Journal of Yeungnam Medical Science Journal of Yeungnam Medical Science 제40권 제1호

발행연도: 2023.1

수록면: 30 - 36 (7page)

DOI: 10.12701/jyms.2022.00059

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Background: Congenital hypothyroidism (CH) is the leading cause of preventable physical and intellectual disabilities. This study aimed to assess the incidence and clinical characteristics of CH in newborns. Methods: We retrospectively reviewed the medical records of all newborns delivered at the Pusan National University Hospital between January 2011 and March 2021. The incidence of CH was compared according to gestational age, birth weight, and small for gestational age (SGA). The patients aged ≥3 years who could not maintain normal thyroid function and required levothyroxine treatment were diagnosed with permanent CH. Logistic regression analysis was performed to compare CH risks. Results: Of 3,722 newborns, 40 were diagnosed with CH (1.07%). Gestational age and birth weight were significantly associated with CH incidence. The odds ratios (ORs) of CH in infants delivered at 32–37, 28–31, and <28 weeks were 2.568 (95% confidence interval [CI], 1.141–5.778), 5.917 (95% CI, 2.264–15.464), and 7.441 (95% CI, 2.617–21.159) times higher, respectively, than those delivered at term. The ORs of CH in infants weighing 1,500–2,499 g, 1,000–1,499 g, and <1,000 g were 4.664 (95% CI, 1.928–11.279), 11.076 (95% CI, 4.089–29.999), and 12.544 (95% CI, 4.350–36.176) times greater, respectively, than those in infants weighing ≥2,500 g. The OR of CH was 6.795 (95% CI, 3.553–13.692) times greater in SGA than in non-SGA infants. Conclusion: The CH incidence in South Korea has increased significantly compared with that in the past. Gestational age, birth weight, and SGA were significantly associated with CH incidence.

#Congenital hypothyroidism #Gestational age #Incidence #Premature infant #Retrospective studies #Small for gestational age infant

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