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논문 기본 정보

자료유형
학술저널
저자정보
Saeed Baradwan (Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center) Abdulrahim Gari (Department of Obstetrics and Gynecology, College of Medicine, Umm Al-Qura University) Hussein Sabban (Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center) Majed Saeed Alshahrani (Department of Obstetrics and Gynecology, Faculty of Medicine, Najran University) Khalid Khadawardi (Department of Obstetrics and Gynecology, College of Medicine, Umm Al-Qura University) Ibtihal Abdulaziz Bukhari (Department of Obstetrics and Gynecology, College of Medicine, Princess Nourah bint Abdulrahman University) Abdullah Alyousef (Department of Obstetrics and Gynecology, King Abdullah bin Abdulaziz University Hospital) Ahmed Abu-Zaid (Department of Obstetrics and Gynecology, College of Medicine, Alfaisal University)
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science Vol.67 No.2
발행연도
2024.3
수록면
186 - 198 (13page)
DOI
10.5468/ogs.23210

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This study aimed to review randomized controlled trials (RCTs) investigating the effects of dietary antioxidant supplements on the severity of endometriosis-related pain symptoms. The PubMed/Medline, Scopus, and Web of Science databases were searched until April 2022. Additionally, we manually searched the reference lists. Endpoints were summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) in a random-effects model. The I<sup>2</sup> statistic was used to assess heterogeneity. Ten RCTs were included in this meta-analysis. Overall, 10 studies were related to dysmenorrhea, four to dyspareunia, and four to pelvic pain. Antioxidants significantly reduced dysmenorrhea (SMD, -0.48; 95% CI, -0.82 to -0.13; I<sup>2</sup>=75.14%). In a subgroup analysis, a significant reduction of dysmenorrhea was observed only in a subset of trials that administered vitamin D (SMD, -0.59; 95% CI, -1.13 to -0.06; I<sup>2</sup>=69.59%) and melatonin (SMD, -1.40; 95% CI, -2.47 to -0.32; I<sup>2</sup>=79.15%). Meta-analysis results also suggested that antioxidant supplementation significantly improved pelvic pain (SMD, -1.51; 95% CI, -2.74 to -0.29; I<sup>2</sup>=93.96%), although they seem not to have a significant beneficial impact on the severity of dyspareunia. Dietary antioxidant supplementation seems to beneficially impact the severity of endometriosis-related dysmenorrhea (with an emphasis on vitamin D and melatonin) and pelvic pain. However, due to the relatively small sample size and high heterogeneity, the findings should be interpreted cautiously, and the importance of further well-designed clinical studies cannot be overstated.

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