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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 1 - 12 (12page)
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초록· 키워드
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A vast community of commensal microorganisms, commonly referred to as the gut microbiota, colonizes the
gastrointestinal tract (GI). The involvement of the gut microbiota in the maintenance of the gut ecosystem is two-fold:
it educates host immune cells and protects the host from pathogens. However, when healthy microbial composition
and function are disrupted (dysbiosis), the dysbiotic gut microbiota can trigger the initiation and development of
various GI diseases, including inflammatory bowel disease (IBD). IBD, primarily includes ulcerative colitis (UC) and
Crohn"s disease (CD), is a major global public health problem affecting over 1 million patients in the United States
alone. Accumulating evidence suggests that various environmental and genetic factors contribute to the pathogenesis
of IBD. In particular, the gut microbiota is a key factor associated with the triggering and presentation of disease.
Gut dysbiosis in patients with IBD is defined as a reduction of beneficial commensal bacteria and an enrichment
of potentially harmful commensal bacteria (pathobionts). However, as of now it is largely unknown whether gut
dysbiosis is a cause or a consequence of IBD. Recent technological advances have made it possible to address this
question and investigate the functional impact of dysbiotic microbiota on IBD. In this review, we will discuss the
recent advances in the field, focusing on host-microbial cross-talk in IBD.
목차
INTRODUCTION
IBD-associated dysbiosis in the gut
The utility of a humanized gnotobiotic mouse system
Discussion
REFERENCES
참고문헌 (99)
참고문헌 신청
Kamada, N., and G. Nunez. 2014. Regulation of the immune system by the resident intestinal bacteria. Gastroenterology 146: 1477-1488.
Honda, K., and D. R. Littman. 2016. The microbiota in adaptive immune homeostasis and disease. Nature 535: 75-84.
Thaiss, C. A., N. Zmora, M. Levy, and E. Elinav. 2016. The microbiome and innate immunity. Nature 535: 65-74.
Kamada, N., G. Y. Chen, N. Inohara, and G. Nunez. 2013. Control of pathogens and pathobionts by the gut microbiota. Nat. Immunol. 14: 685-690.
Kamada, N., S. U. Seo, G. Y. Chen, and G. Nunez. 2013. Role of the gut microbiota in immunity and inflammatory disease. Nat. Rev. Immunol. 13: 321-335.
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UCI(KEPA) : I410-ECN-0101-2017-517-002233559