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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 468 - 473 (6page)
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Purinergic receptor signaling is increasingly recognized as an important regulator of inflammation. The P2X family purinergic receptors P2X5 and P2X7 have both been implicated in bone biology, and it has been suggested recently that P2X5 may be a significant regulator of inflammatory bone loss. However, a role for P2X5 in periodontitis is unknown. The present study aimed to evaluate the functional role of P2X5 in ligatureinduced periodontitis in mice. Five days after placement of ligature, analysis of alveolar bone revealed decreased bone loss in P2rx5−/− mice compared to P2rx7−/− and WT control mice. Gene expression analysis of the gingival tissue of ligated mice showed that IL1b, IL6, IL17a and Tnfsf11 expression levels were significantly reduced in P2rx5−/− compared to WT mice. These results suggest the P2X5 receptor may regulate bone loss related to periodontitis and it may thus be a novel therapeutic target in this oral disease.
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참고문헌 (39)
참고문헌 신청
Frencken JE / 2017 / Global epidemiology of dental caries and severe periodontitis - a comprehensive review / J Clin Periodontol 44(Suppl 18):S94~S105
Hajishengallis G / 2014 / Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response / Trends Immunol 35:3~11
Hajishengallis G / 2015 / Periodontitis: from microbial immune subversion to systemic inflammation / Nat Rev Immunol 15:30~44
Zenobia C / 2014 / Porphyromonas gingivalis lipid A phosphatase activity is critical for colonization and increasing the commensal load in the rabbit ligature model / Infect Immun 82:650~659
Thunell DH / 2010 / A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy / J Periodontal Res 45:148~152
Hajishengallis G / 2014 / Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response / Trends Immunol 35:3~11
Hajishengallis G / 2015 / Periodontitis: from microbial immune subversion to systemic inflammation / Nat Rev Immunol 15:30~44
Zenobia C / 2014 / Porphyromonas gingivalis lipid A phosphatase activity is critical for colonization and increasing the commensal load in the rabbit ligature model / Infect Immun 82:650~659
Thunell DH / 2010 / A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy / J Periodontal Res 45:148~152
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