지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 322 - 329 (8page)
이용수
초록· 키워드
오류제보하기
Purpose The specific targeting of interleukin-4 receptor α (IL4Rα) receptor offers a promising therapeutic approach for inhibition of tumor cell progression in breast cancer patients. In the current study, the in vitro efficacy of superparamagnetic iron oxide nanoparticles conjugated with anti-IL4Rα blocking antibodies (SPION-IL4Rα) via polyethylene glycol polymers was evaluated in 4T1 breast cancer cells.
Materials and Methods Cell viability, reactive oxygen species generation, and apoptosis frequency were assessed in vitro in 4T1 cancer cell lines following exposure to SPION-IL4Rα alone or combined with doxorubicin. In addition, immunofluorescence assessments and fluorimetry were performed to confirm the specific targeting and interaction of the developed nanocarriers with IL4Rα receptors in breast cancer cells.
Results Blocking of IL4Rα receptors caused a significant decrease in cell viability and induced apoptosis in 4T1 cells. In addition, combined treatment with SPION-IL4Rα+doxorubicin caused significant increases in cell death, apoptosis, and oxidative stress compared to either SPIONIL4Rα or doxorubicin alone, indicating the enhanced therapeutic efficacy of this combination.
The decrease in fluorescence intensity upon immunofluorescence and fluorimetry assays combined with increased viability and decreased apoptosis following the blocking of IL4Rα receptors confirmed the successful binding of the synthesized nanocarriers to the target sites on murine 4T1 breast cancerous cells.
Conclusion These results suggest that SPION-IL4Rα nanocarriers might be used for successful reduction of tumor growth and inhibition of progression of metastasis in vivo.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Al Faraj A / 2015 / Effect of surface coating on the biocompatibility and in vivo MRI detection of iron oxide nanoparticles after intrapulmonary administration / Nanotoxicol
Al Faraj A / 2015 / Magnetic single-walled carbon nanotubes as efficient drug delivery nanocarriers in breast cancer murine model : noninvasive monitoring using diffusion-we
Al Faraj A / 2016 / Specific targeting and noninvasive imaging of breast cancer stem cells using single-walled carbon nanotubes as novel multimodality nanoprobes / Nanomedici
Al Faraj A / 2016 / Specific targeting and noninvasive magnetic resonance imaging of an asthma biomarker in the lung using polyethylene glycol functionalized magnetic nanoca
Ben-Baruch A / 2003 / Host microenvironment in breast cancer development : inflammatory cells, cytokines and chemokines in breast cancer progression : reciprocal tumormicroen
Al Faraj A / 2015 / Magnetic single-walled carbon nanotubes as efficient drug delivery nanocarriers in breast cancer murine model : noninvasive monitoring using diffusion-we
Al Faraj A / 2016 / Specific targeting and noninvasive imaging of breast cancer stem cells using single-walled carbon nanotubes as novel multimodality nanoprobes / Nanomedici
Al Faraj A / 2016 / Specific targeting and noninvasive magnetic resonance imaging of an asthma biomarker in the lung using polyethylene glycol functionalized magnetic nanoca
Ben-Baruch A / 2003 / Host microenvironment in breast cancer development : inflammatory cells, cytokines and chemokines in breast cancer progression : reciprocal tumormicroen
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
Out-sourcing for Trans-presentation : Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
2018 .02
-
Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
Immune Network
2021 .10
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
IL4 receptor activation in breast and colon cancer
한국실험동물학회 학술발표대회 논문집
2019 .07
-
췌장암 환자의 IL-6 수치와 암 진행의 상관 관계에 대한 3례 증례보고
대한한방내과학회지
2024 .06
-
Understanding EGFR Signaling in Breast Cancer and Breast Cancer Stem Cells: Overexpression and Therapeutic Implications
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Recent Progress in HER2 Associated Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis
The Korean Journal of Physiology & Pharmacology
2018 .09
-
Association of Estrogen Receptor Alpha and Interleukin 6 Polymorphisms with Lymphovascular Invasion, Extranodal Extension, and Lower Disease-Free Survival in Thai Breast Cancer Patients
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
Expression of Il4rα and Il13rα1 in Gallbladder Cancer
대한외과학회 학술대회 초록집
2021 .11
-
Association of Single Nucleotide Polymorphisms in Interleukin-12 Receptor (IL-12Rβ1 and IL-12Rβ2) with Asthma in a Korean Population
대한의생명과학회지
2020 .12
-
Predictive Factors of Pathologic N2/N3 Disease in Clinical or Pathologic N1 ER+/HER2- Breast Cancer
대한외과학회 학술대회 초록집
2023 .05
-
Tp53 Mutation Is Linked with High 21-Gene Recurrence Score in ER+/HER2- Breast Cancer
대한외과학회 학술대회 초록집
2021 .05
-
Breast Cancer
대한외과학회 학술대회 초록집
2020 .11
-
Breast Cancer
대한외과학회 학술대회 초록집
2022 .11
-
Breast Cancer
대한외과학회 학술대회 초록집
2022 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0