개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Gut microbiota contributes to intestinal and immune homeostasis through host-microbiota interactions. Distribution of the gut microbiota differs according to the location in the gastrointestinal tract. Although the microbiota properties change with age, evidence for the regional difference of gut microbiota has been restricted to the young. The aim of this study is to compare the gut microbiota between terminal ileum and cecum of old rats. Methods: We analyzed gut microbiome of luminal contents from ileum and cecum of 74-week-old and 2-year-old rats (corresponding to 60-year and 80-year-old of human age) by metagenome sequencing of 16S rRNA. Results: Inter-individual variation (beta diversity) of microbiota was higher in ileum than in cecum. Conversely, alpha diversity of microbiota composition was higher in cecum than in ileum. Lactobacillaceae were more abundant in ileum compared to cecum while Ruminococcaceae and Lachnospiraceae were more enriched in cecum. The proportions of Deltaproteobacteria were increased in cecal microbiota of 2-year-old rats compared to 74-week-old rats. Conclusions: Major regional distinctions of microbiota between ileum and cecum of old rats appear consistent with those of young rats. Age-related alterations of gut microbiota in old rats seem to occur in minor compositions.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Rakoff-Nahoum S / 2004 / Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis / Cell 118:229~241
Stappenbeck TS / 2002 / Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells / Proc Natl Acad Sci U S A 99:15451~15455
Backhed F / 2004 / The gut microbiota as an environmental factor that regulates fat storage / Proc Natl Acad Sci U S A 101:15718~15723
Rowland I / 2018 / Gut microbiota functions: metabolism of nutrients and other food components / Eur J Nutr 57:1~24
Sekirov I / 2010 / Gut microbiota in health and disease / Physiol Rev 90:859~904
Stappenbeck TS / 2002 / Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells / Proc Natl Acad Sci U S A 99:15451~15455
Backhed F / 2004 / The gut microbiota as an environmental factor that regulates fat storage / Proc Natl Acad Sci U S A 101:15718~15723
Rowland I / 2018 / Gut microbiota functions: metabolism of nutrients and other food components / Eur J Nutr 57:1~24
Sekirov I / 2010 / Gut microbiota in health and disease / Physiol Rev 90:859~904
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
소아과학 관점에서 바라본 장내 미생물 연구 동향과 향후 방향
대한한방소아과학회지
2019 .01
-
Alteration of Gut Microbiota in Autism Spectrum Disorder: An Overview
소아청소년정신의학
2020 .07
-
Changes in Cecal Microbiota and Short-chain Fatty Acid During Lifespan of the Rat
Journal of Neurogastroenterology and Motility (JNM)
2021 .01
-
Microbiota: A Key for Healthy Aging
Annals of geriatric medicine and research
2016 .01
-
The impact of the microbiota on animal models and how to handle it
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Gut Microbiota and Metabolic Disorders
Diabetes and Metabolism Journal
2015 .01
-
Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study
Gut and Liver
2016 .01
-
Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders: A Clinical Perspective
Journal of Neurogastroenterology and Motility (JNM)
2018 .01
-
Gut microbiota in pathophysiology, diagnosis, and therapeutics of inflammatory bowel disease
Intestinal research
2024 .01
-
Revolutionizing gut health: exploring the role of gut microbiota and the potential of microbiome-based therapies in lower gastrointestinal diseases
고신대학교 의과대학 학술지
2023 .06
-
The Gut-Brain Axis: The Missing Link in Depression
Clinical Psychopharmacology and Neuroscience
2015 .01
-
Intestinal PPARγ signaling controls tumor growth via gut microbiota
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Microbiota Influences Vaccine and Mucosal Adjuvant Efficacy
Immune Network
2017 .02
-
비만에서의 장내 미생물 무리의 역할
대한내과학회지
2019 .10
-
Role of the Gut Microbiota in Regulating Responses to anti-PD-1 Cancer Immunotherapy
대한임상종양학회 학술대회지
2021 .06
-
A mechanism-based understanding of altered drug pharmacokinetics by gut microbiota
Journal of Pharmaceutical Investigation
2023 .01
-
Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome
Gut and Liver
2015 .01
-
Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats
Gut and Liver
2019 .01
-
The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study
Annals of Surgical Treatment and Research
2021 .11
-
Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model
한국실험동물학회 학술발표대회 논문집
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0