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논문 기본 정보

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저자정보
Soo In Choi (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Kor) Joo Hee Son (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Kor) Nayoung Kim (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Kor) Yong Sung Kim (Digestive Disease Research Institute and DCNbio research center Wonkwang University Iksan Jeollabuk) Ryoung Hee Nam (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Kor) Ji Hyun Park (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Chin-Hee Song (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Kor) Jeong Eun Yu (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Kor) Dong Ho Lee (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Kor) Kichul Yoon (Department of Internal Medicine Wonkwang University Sanbon Medical Center Gunpo-si Gyeonggi-do Kore) Huitae Min (Department of Biological Sciences and Institute of Microbiology Seoul National University Seoul Kor) Yeon-Ran Kim (Department of Biological Sciences and Institute of Microbiology Seoul National University Seoul Kor) Yeong-Jae Seok (Department of Biological Sciences and Institute of Microbiology Seoul National University Seoul Kor)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.27 No.1
발행연도
2021.1
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134 - 146 (13page)

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Background/AimsThe gut microbiota regulates intestinal immune homeostasis through host-microbiota interactions. Multiple factors affect the gut microbiota, including age, sex, diet, and use of drugs. In addition, information on gut microbiota differs depending on the samples. The aim of this study is to investigate whether changes in cecal microbiota depend on aging. MethodsGut microbiota in cecal contents of 6-, 31-, and 74-week-old and 2-year-old male Fischer-344 rats (corresponding to 5-, 30-, 60-, and 80-year-old humans in terms of age) were analyzed using 16S ribosomal RNA metagenome sequencing and phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) based on the Kyoto Encyclopedia of Genes and Genomes orthology. Moreover, short-chain fatty acid (SCFA) level in cecum and inflammation related factors were measured using real-time quantitative polymerase chain reaction and enzyme linked immunosorbent assay. ResultsAlpha and beta diversity did not change significantly with age. At the family level, Lachnospiraceae and Ruminococcaceae, which produce SCFAs, showed significant change in 31-week-old rats: Lachnospiraceae significantly increased at 31 weeks of age, compared to other age groups, while Ruminococcaceae decreased. Butyrate levels in cecum were significantly increased in 31-week-old rats, and the expression of inflammation related genes was increased followed aging. Especially, EU622775_s and EU622773_s, which were highly abundance species in 31-week-old rats, showed significant relationship with butyrate concentration. Enzymes required for producing butyrate—acetyl-CoA transferase, butyryl-CoA dehydrogenase, and butyrate kinase—were not predicted by PICRUSt. ConclusionsMajor bacterial taxa in the cecal lumen, such as Lachnospiraceae, well-known SCFAs-producing family, changed in 31-week-old rats. Moreover, unknown species EU622775_s and EU622773_s showed strong association with cecal butyrate level at 31 weeks of age.
#Aging #Butyrate #Cecum #Microbiota #Rats

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참고문헌 (38)

참고문헌 신청
Canny GO / 2008 / Bacteria in the intestine, helpful residents or enemies from within? / Infect Immun 76:3360~3373 google schola Quigley EM / 2013 / Gut bacteria in health and disease / Gastroenterol Hepatol 9:560~569 google schola Nguyen TL / 2015 / How informative is the mouse for human gut microbiota research? / Dis Model Mech 8:1~16 google schola Flemer B / 2017 / Fecal microbiota variation across the lifespan of the healthy laboratory rat / Gut Microbes 8:428~439 google schola Li D / 2017 / Microbial biogeography and core microbiota of the rat digestive tract / Sci Rep 8:45840 google schola

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