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자료유형
학술저널
저자정보
Yukari Tanaka (Tohoku Medical Megabank Organization Tohoku University Sendai Japan) Motoyori Kanazawa (Department of Behavioral Medicine Tohoku University Graduate School of Medicine Sendai Japan) Olafur S Palsson (Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill NC USA) Miranda A Van Tilburg (Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill NC USA) Lisa M Gangarosa (Center for Functional GI and Motility Disorders University of North Carolina at Chapel Hill NC USA) Shin Fukudo (Department of Behavioral Medicine Tohoku University Graduate School of Medicine Sendai Japan) Douglas A Drossman (University of North Carolina School of Medicine Chapel Hill North Carolina USA) William E Whitehead (University of North Carolina School of Medicine Chapel Hill North Carolina USA)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.1
발행연도
2018.1
수록면
87 - 95 (9page)

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Background/Aims The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV is correlated with colonic motility and IBS symptoms. Methods One hundred and fifty-six Rome III positive IBS patients and 31 healthy controls underwent colonic manometry with bag distention in the descending colon, followed by ingestion of an 810-kcal meal. HRV, evaluated by low frequency (%LF; 0.04–0.15 Hz) component, high frequency (%HF; 0.15–0.40 Hz) component, and the LF/HF ratio, was measured during colonic distention and after the meal. Motility index and subjective symptom scores were simultaneously quantified. Results Both colonic distention and eating decreased %HF and increased the LF/HF ratio, and both indices of autonomic nervous system correlated with age. In IBS patients, %HF negatively correlated with the postprandial motility index after adjusting for age. The %HF and LF/HF ratios also correlated with psychological symptoms but not bowel symptoms in IBS patients. Conclusion Decreased vagal activity is associated with increase in age and greater postprandial colonic motility in patients with IBS, which may contribute to postprandial symptoms.

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