Tumor Necrosis Factor-Alpha and Interleukin-4 Levels in Patients With Idiopathic Sudden Sensorineural Hearing Loss

김연; 김수종; 최석열; 문지원; 최준; 임기정; 채성원; 송재준

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자료유형: 학술저널

저자정보: 김연 (고려대학교) 김수종 (고려대학교) 최석열 (고려대학교) 문지원 (고려대학교) 최준 (고려대학교) 임기정 (고려대학교) 채성원 (고려대학교) 송재준 (고려대학교)

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후-두경부외과학회지 제64권 제9호

발행연도: 2021.9

수록면: 626 - 634 (9page)

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Background and Objectives The pathogenesis of idiopathic sudden sensorineural hearingloss (ISSNHL), an otologic emergency disease, remains unclear. Several studies have attemptedto illustrate the association between cytokines and ISSNHL. The purpose of this study wasto evaluate the prognostic significance of various cytokines in patients with ISSNHL. Subjects and Method In this case-control study, a total of 55 patients with ISSNHL underwenttreatment with oral prednisolone for 2 weeks. Serum cytokine levels, including interleukins(ILs) (IL-1a, IL-1b, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12), and tumor necrosis factors(TNF-α and TNF-β), were measured using human cytokine panels at first visit. Patient characteristicssuch as age, gender, the status of hypertension, diabetes mellitus, vertigo, timefrom onset to visit, and initial hearing levels were also evaluated. Results Serum levels of cytokines were correlated with the prognosis of ISSNHL patients. IL-4 ≥0.225 (pg/mL) and TNF-α ≥5.155 (pg/mL) were significantly associated with poor therapeuticoutcomes (OR=44.317, p=0.015 and OR=269.465, p=0.006, respectively). In addition,age and initial hearing levels were also significant prognostic factors. Conclusion Patients’ age, initial hearing levels, and serum levels of IL-4 and TNF-α prior totreatment are associated with hearing recovery and can be used as prognostic factors for patientswith ISSNHL.

#Interleukins #Sensorineural hearing loss #Sudden deafness #Tumor necrosis factor-alpha

참고문헌 (40)

참고문헌 신청

Conlin AE / 2007 / Treatment of sudden sensorineural hearing loss: I. A systematic review / Arch Otolaryngol Head Neck Surg 133(6):573~581

Merchant SN / 2005 / Patholog y and pathophysiology of idiopathic sudden sensorineural hearing loss / Otol Neurotol 26(2):151~160

Scheller J / 2011 / The proand anti-inflammatory properties of the cytokine interleukin-6 / Biochim Biophys Acta 1813(5):878~888

Kassner SS / 2011 / Proinflammatory and proadhesive activation of lymphocytes and macrophages in sudden sensorineural hearing loss / Audiol Neurootol 16(4):254~262

Merchant SN / 2008 / Sudden deafness : Is it viral / ORL J Otorhinolaryngol Relat Spec 70(1):52~60

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