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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 105 - 110 (6page)
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초록· 키워드
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Background: Major burn injuries induce inflammatory responses and changes in the levels of various cytokines. This study was conducted to assess early changes in the serum levels of inflammatory cytokines after burn injury, identify cytokines associated with mortality, and characterize correlations among cytokines.
Methods: Blood samples of 67 burn patients were collected on days 1 and 3 after burn injury, and the concentrations of 27 cytokines were measured using the Bio-Plex Suspension Array System (Bio-Rad Laboratories, USA). Blood samples of 25 healthy subjects were used as controls. We analyzed statistical differences in the concentrations of each cytokine between the control and patient groups, between day 1 and day 3, and between survival and nonsurvival groups. Correlations among 27 cytokines were analyzed.
Results: Median concentrations of granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin 1 receptor antagonist (IL-1RA), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), interleukin 15 (IL-15), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein 1β (MIP-1β), and vascular endothelial growth factor (VEGF) were significantly higher in burn patients than in controls. IL-1RA, IL-6, and MCP-1 levels were significantly higher in the nonsurvival group than in the survival group on day 1 after burn injury. Correlation analysis of 27 cytokines showed different relationships with one another. Stronger correlations among interferon γ (IFN-γ), IL-2, IL-4, IL-7, IL-12p70, and IL-17 were found.
Conclusions: IL-1RA, IL-6, and MCP-1 may be used as prognostic indicators of mortality in burn patients and the increase in cytokine concentrations is induced by interactions within a complex network of cytokine-related pathways.
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참고문헌 (11)
참고문헌 신청
Csontos C / 2010 / Time course of pro- and anti-inflammatory cytokine levels in patients with burns-prognostic value of interleukin-10 / Burns 36 : 483 ~ 494
Davis CS / 2013 / Inhalation injury severity and systemic immune perturbations in burned adults / Ann Surg 257 : 1137 ~ 1146
Elias JA / 1990 / Cytokine networks in the regulation of inflammation and fibrosis in the lung / Chest 97 : 1439 ~ 1445
Finnerty CC / 2006 / Cytokine expression profile over time in severely burned pediatric patients / Shock 26 : 13 ~ 19
Finnerty CC / 2008 / Temporal cytokine profiles in severely burned patients: a comparison of adults and children / Mol Med 14 : 553 ~ 560
Davis CS / 2013 / Inhalation injury severity and systemic immune perturbations in burned adults / Ann Surg 257 : 1137 ~ 1146
Elias JA / 1990 / Cytokine networks in the regulation of inflammation and fibrosis in the lung / Chest 97 : 1439 ~ 1445
Finnerty CC / 2006 / Cytokine expression profile over time in severely burned pediatric patients / Shock 26 : 13 ~ 19
Finnerty CC / 2008 / Temporal cytokine profiles in severely burned patients: a comparison of adults and children / Mol Med 14 : 553 ~ 560
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