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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 438 - 445 (8page)
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초록· 키워드
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Background: Pemphigus is a group of autoimmune blistering diseases affecting skin and mucous membranes. While pemphigus is an autoantibody mediated disease, the role of T cells and cytokines in the pathogenesis is being increasingly recognized. Objective: This study was conducted to observe alterations in the serum cytokine levels of patients with pemphigus vulgaris (PV), pemphigus foliaceous (PF), paraneoplastic pemphigus (PNP) and compare with bullous pemphigoid (BP) and healthy subjects. Methods: A total of 75 subjects (28 PV, 13 PF, 7 PNP, 7 BP, and 20 healthy controls) were included, all patients in active disease state. Serum levels of interferon (IFN)-γ, interleukin (IL)-4, IL-6, IL-17A, IL-10, tumor necrosis factor (TNF)-α, and IL-8 were measured by enzyme-linked immunosorbent assay. Results: The median concentration of IFN-γ was lower in PV and BP patients compared to control (0.77, 0.34 and 1.63 pg/ml, respectively).
IL-6 and IL-10 was significantly higher in PNP patients compared to control (4.92 and 0.24 pg/ml for IL-6, 0.86 and ＜0.12 pg/ml for IL-10, respectively). IL-8 was increased significantly in PV and PNP patients compared with control (11.85, 31.5 and 8.31 pg/ml, respectively). For IL-4, IL-17A and TNF-α, no significant difference was observed between the five groups. Conclusion: The decreased level of IFN-γ in PV may imply suppressed Th1 response in the active disease stage. A Th2 predominant response is suggested in the active stage of PNP, with elevated serum levels of IL-6 and IL-10.
Increased level of proinflammatory cytokine IL-8 is observed in the sera of PV and PNP patients.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alecu M / 1999 / ICAM-1, ELAM-1, TNF-alpha and IL-6 in serum and blister liquid of pemphigus vulgaris patients / Roum Arch Microbiol Immunol 58 : 121 ~ 130
Anhalt GJ / 1990 / Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia / N Engl J Med 323 : 1729 ~ 1735
Arakawa M / 2009 / Lesional Th17 cells in pemphigus vulgaris and pemphigus foliaceus / J Dermatol Sci 53 : 228 ~ 231
Baroni A / 2002 / Cytokine pattern in blister fluid and sera of patients with pemphigus / Dermatology 205 : 116 ~ 121
Choi Y / 2012 / Retrospective analysis of 12 Korean patients with paraneoplastic pemphigus / J Dermatol 39 : 973 ~ 981
Anhalt GJ / 1990 / Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia / N Engl J Med 323 : 1729 ~ 1735
Arakawa M / 2009 / Lesional Th17 cells in pemphigus vulgaris and pemphigus foliaceus / J Dermatol Sci 53 : 228 ~ 231
Baroni A / 2002 / Cytokine pattern in blister fluid and sera of patients with pemphigus / Dermatology 205 : 116 ~ 121
Choi Y / 2012 / Retrospective analysis of 12 Korean patients with paraneoplastic pemphigus / J Dermatol 39 : 973 ~ 981
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