지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제6호
- 발행연도
- 2021.10
- 수록면
- 575 - 583 (9page)
- DOI
- 10.4196/kjpp.2021.25.6.575
이용수
초록· 키워드
오류제보하기
Composition of the gut microbiota changes with aging and plays an important role in age-associated disease such as metabolic syndrome, cancer, and neurodegeneration. The gut microbiota composition oscillates through the day, and the disruption of their diurnal rhythm results in gut dysbiosis leading to metabolic and immune dysfunctions. It is well documented that circadian rhythm changes with age in several biological functions such as sleep, body temperature, and hormone secretion. However, it is not defined whether the diurnal pattern of gut microbial composition is affected by aging. To evaluate aging effects on the diurnal pattern of the gut microbiome, we evaluated the taxa profiles of cecal contents obtained from young and aged mice of both sexes at daytime and nighttime points by 16S rRNA gene sequencing. At the phylum level, the ratio of Firmicutes to Bacteroidetes and the relative abundances of Verrucomicrobia and Cyanobacteria were increased in aged male mice at night compared with that of young male mice. Meanwhile, the relative abundances of Sutterellaceae, Alloprevotella, Lachnospiraceae UCG-001, and Parasutterella increased in aged female mice at night compared with that of young female mice. The Lachnospiraceae NK4A136 group relative abundance increased in aged mice of both sexes but at opposite time points. These results showed the changes in diurnal patterns of gut microbial composition with aging, which varied depending on the sex of the host. We suggest that disturbed diurnal patterns of the gut microbiome can be a factor for the underlying mechanism of age-associated gut dysbiosis
목차
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참고문헌 (46)
참고문헌 신청
Bishehsari F / 2020 / Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer / Nat Rev Endocrinol 16:731~739
Vijay-Kumar M / 2010 / Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5 / Science 328:228~231
Samuel BS / 2008 / Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 / Proc Natl Acad Sci U S A 105:16767~16772
Turnbaugh PJ / 2006 / An obesity-associated gut microbiome with increased capacity for energy harvest / Nature 444:1027~1031
Biagi E / 2016 / Gut microbiota and extreme longevity / Curr Biol 26:1480~1485
Vijay-Kumar M / 2010 / Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5 / Science 328:228~231
Samuel BS / 2008 / Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 / Proc Natl Acad Sci U S A 105:16767~16772
Turnbaugh PJ / 2006 / An obesity-associated gut microbiome with increased capacity for energy harvest / Nature 444:1027~1031
Biagi E / 2016 / Gut microbiota and extreme longevity / Curr Biol 26:1480~1485
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