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자료유형
학술저널
저자정보
Yeon-Hee Lee (Kyung Hee University School of Dentistry) Sung-Woo Lee (Seoul National University School of Dentistry) Hak Young Rhee (Kyung Hee University School of Medicine) Min Kyu Sim (Seoul National University of Science and Technology) Su-Jin Jeong (Kyung Hee University Medical Center) Chang Won Won (Kyung Hee University)
저널정보
대한치의학회 Journal of Korean Dental Science Journal of korean dental science Vol.16 No.2
발행연도
2023.12
수록면
128 - 148 (21page)

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초록· 키워드

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Dementia is an umbrella term that describes the loss of thinking, memory, attention, logical reasoning, and other mental abilities to the extent that it interferes with the activities of daily living. More than 50 million individuals worldwide live with dementia, which is expected to increase to 131 million by 2050. Recent research has shown that poor oral health increases the risk of dementia, while oral health declines with cognitive decline. In this narrative review, the literature was based on the “hypothesis” that dementia and oral health have a close relationship, and appropriate oral health and occlusal rehabilitation treatment can improve the quality of life of patients with dementia and prevent progression. We conducted a literature search in PubMed and Google Scholar databases, using the search terms “dementia,” “major neurocognitive disorder,” “dentition,” “occlusion,” “tooth loss,” “dental prosthesis,” “dental implant,” and “occlusal rehabilitation” in the title field over the past 30 years. A total of 131 studies that scientifically addressed dementia, oral health, and/or oral rehabilitation were included. In a meta-analysis, the random effect model demonstrated significant tooth loss increasing the dementia risk 3.64-fold (pooled odds ratio=3.64, 95% confidence interval [2.50~5.32], P-value=0.0348). Tooth loss can be an important indicator of cognitive function decline. As the number of missing teeth increases, the risk of dementia increases. Loss of teeth can lead to a decrease in the ascending information to the brain and reduced masticatory ability, cerebral blood flow, and psychological atrophy. Oral microbiome dysbiosis and migration of key bacterial species to the brain can also cause dementia. Additionally, inflammation in the oral cavity affects the inflammatory response of the brain and the complete body. Conversely, proper oral hygiene management, the placement of dental implants or prostheses to replace lost teeth, and the restoration of masticatory function can inhibit symptom progression in patients with dementia. Therefore, improving oral health can prevent dementia progression and improve the quality of life of patients.

목차

Introduction
Method
Definition and Characterization of Dementia
Progression of Dementia
Pathophysiology of Dementia
General Risk Factors for Dementia
Oral Health and Dementia-Poor Oral Health as a Risk Factor for Dementia
Oral Health and Prevention of Dementia with Oral Health Care
Conclusion
References

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